名师简介
教育背景及工作经历： 1970年毕业于清华大学工化系，同年留清华大学任教 1979-1982年在北京工业大学读研究生获硕士学位 同年到首都医科大学任教 1989-1990年世界卫生组织资助到匈牙利Jozsef大学进修无机生物化学 1990年涉足酶学研究，1998年北京科技进步二等奖 科研方向： 化学-生物学相互作用（生物体内重要的酶的抑制机理与抑制剂的生物学效应） 代表性论文： 1、Kinetics of the Course of Reactivation of Aminoacylase reconstituted Using Mn2+ Ions. J. of Protein Chemistry: 1995, 14 (8) 2、Kinetics of Irreversible Inhibition of Yeast Alcohol Dehydrogenase during Modification by 0---Phthaldehyde. Enzyme Protein: 1995, 48, 183-190 3、Kinetics of the course of inactivation YADH. J. of Enzyme Inhibition :1996. 10（4） 4、Inactivation and Conformational Changes of aminoacylase in TFE solutions. J. of Protein Chemistry: 1996, 15（7） 5、Acid-Induced Folding of Yeast Alcohol dehydrogenase under Low pH conditions. J. of Biochemistry: 1996, 119,674-679 6、Interaction of Eu3+ with yeast Alcohol Dehydrogenase. J. of Protein Chemistry : 1999, 18 (1) 7、Conformational Changes and inactivation of CIAP in TFE solutions. The international Journal of Biochemistry and cell Biology: 2000, 32 (8) 8、Refolding and reactivation of Calf intestinal alkaline phosphatase With excess magnesium ions. The international Journal of Biochemistry and cell Biology: 2002, 34,1241-47 9、The Unfolding Intermediate State of Calf Intestinal Alkaline Phosphatase during Denaturation in Guanidine Solutions. Journal of Protein Chemistry: 2003,22 (5) 10、Study of Refolding of Calf Intestinal Alkaline Phosphatase Effect of Extraneous Zinc on. Journal of Protein Chemistry: 2003,22 (5) 11、Calf Intestinal Alkaline Phosphatase. Journal of Protein Chemistry: 2003, 22 (4) 12、Effect of magnesium on thermal inactivation of alkaline phosphatase. The Protein Journal: 2005 , 24(7) 13、The Extract of leaves of Acer truncatum Bunge: A Natural Inhibitor of Fatty Acid Synthase with antitumor activity. Journal of Enzyme Inhibition and Medicinal Chem: 2006, 21( ) 14、Comparison of Inactivation and Unfolding of Calf Intestinal Alkaline Phosphatase in GdnHCl. 清华大学学报 (英文版) E I收录: 2002, 7(4) 425-9 15.. The isolation of 1,2,3,4,6-penta-O-galloyl-beta-d-glucose from Acer truncatum Bunge by high-speed counter-current chromatography. Journal of Chromatography B, (2006) Available online 1 December 2006 in press. SCI 收录期刊, 影响因子 2.39. 16. Evaluation of The Inhibitory Activities of Aceraceous Plants on Fatty Acid Synthase, Journal of Enzyme Inhibition and Medicinal Chemistry , 2007, 已接受。SCI 收录期刊，影响因子 1.667. 发明专利： 1．国家发明专利：申请号200610088901.6，题目 脂肪酸合酶抑制剂—槭树科槭树属植物的提取物以及应用。 2．国家发明专利： 申请号200510068054.2 题目 脂肪酸合酶抑制剂及其制备方法与以其为活性成分的药物。 联系方式: 地址：首都医科大学化学生物学与药学院化学生物学系 邮编：100069 Tel: 010-83911522 Email: zhangyue@ccmu.edu.cn