徐小龙

徐小龙 副教授 电 话： 0551－3603214 电子邮件： xuxl@ustc.edu.cn 传 真： 主页： 个人简历 1989.9 - 1992.3 中国科学技术大学应用化学系，硕士 1997.9 - 2000.6 中国科学技术大学化学系，博士 2000.7 - 2001.11 中国科学技术大学化学系，讲师 2001.12 - 至今 中国科学技术大学化学系，副教授 2003.6 - 2005.8 加拿大生物技术研究所，博士后 主要研究方向 1． 蛇毒蛋白的结构、性质和功能 2． 金属离子与蛋白质相互作用 3． 蛋白质折叠机理 4． 细胞内信号调节蛋白作用机理 获奖及荣誉 1994年安徽省自然科学论文一等奖 2000年中国科学技术大学郭沫若奖 文章及专著 1. Xiaolong Xu, Qingliang Liu, and Yongshu Xie. Metal ion-induced stabilization and refolding of anticoagulation factor II from the venom of Agkistrodon acutus. Biochemistry, 2002，41, 3546-3554. 2. Zhengding Su, Michael J. Osborne, Ping Xu, Xiaolong Xu, Yang Li, Feng Ni. A bivalent dissectional analysis of the high-affinity interactions between Cdc42 and the Cdc42/Rac interactive binding domains of signaling kinases in Candida albicans. Biochemistry, 2005, 44, 16461-16474. 3. Xiaolong Xu, Qingliang Liu, Huaming Yu and Yongshu Xie. Ca(II) and Tb(III)-induced stabilization and refolding of anticoagulation factor I from the venom of Agkistrodon acutus. Protein Science, 2002,11, 944-956. 4. Xiaolong Xu, Jiexia Chen, Liyun Zhang, Xianghu Liu, Wenqi Liu, Qingliang Liu. Effects of rare earth ions on the conformational stability of anticoagulation factor II from Agkistrodon acutus venom probed by fluorescent spectroscopy. Biopolymers, 2006, in press. 5. Xiaolong Xu, Xianghu Liu, Bin Wu, Yi Liu, Wenqi Liu, Yongshu Xie, Qingliang Liu. Metal ions- and pH-induced conformational changes of acutolysin D from Agkistrodon acutus venom probed by fluorescent spectroscopy. Biopolymers, 2004, 74, 336-344. 6. Xiaolong Xu, Qingliang Liu, Bin Wu, Yongshu Xie. Effects of terbium and pH on structure of anticoagulation factor II from Agkistrodon acutus venom probed by fluorescent spectroscopy and equilibrium dialysis. Biopolymers, 2002, 67, 387-393. 7. Xiaolong Xu, Qingliang Liu. Binding of anticoagulation factor II from the venom of Agkistrodon acutus with activated coagulation factor X. Toxicon, 2001, 39, 1359-1365. 8. Xiaolong Xu, Qingliang Liu, Yongshu Xie, Shuangding Wu. Purification and characterization of anticoagulation factors from the venom of Agkistrodon acutus. Toxicon, 2000, 38, 1517-1528. 9. Shuangding Wu, Xiaolong Xu, Yongshu Xie, Lixin Chen, Zhenlong Chen, and Qingliang Liu. Cu(II) coordination structure in NAD glycohydrolase from Agkistrodon acutus venom studied by EPR spectroscopy. Chem. Lett., 2002, 3, 354-355. 10. Xiaolong Xu, Qingliang Liu Shuangding Wu. The binding of the anticoagulation factor I from the venom of Agkistrodon acutus with activated factor X. Chinese Science Bulletin. 2000, 45, 1296-1300.